| SCREENKIDS | 08437029661028 | BCNINNOVA TECHNOLOGICAL EVOLUTION SL | Class I | |
| Scrivo Bene | 08053840920061 | One Health Vision | Class I | |
| Sea of Heroes: New World | 08437025783007 | Sincrolab SL | Class IIa | |
| Sectra RIS (E) 27.2 | 07350092810647 | Sectra AB | Class I | |
| Sectra RIS (E) 28.1 | 07350092810692 | Sectra AB | Class I | |
| Sectra RIS (E) 28.2 | 07350092810746 | Sectra AB | Class I | |
| Secur'Way | 03760390880015 | SOFTWAY MEDICAL | Class IIb | |
| Sedakit | 03770022767218 | YBIA SAS | Class I | |
| Seegnal Software | 07290020107008 | Seegnal eHealth Ltd. | Class I | |
| SelectEat | 08058754590027 | Digitherapix S.R.L. | Class I | |
| Selfapy | 04260739130027 | Selfapy GmbH | Class I | |
| Selfapy | 04260755490051 | Medigital GmbH | Class I | |
| Sensiplan+ »configuration Woman«, Android version 1 | 03830087911008 | WONDERLIFE raziskovanje, ustvarjanje, svetovanje in izobraževanje d.o.o. | Class I | |
| Sensiplan+ »configuration Woman«, iOS version 1 | 03830087913002 | WONDERLIFE raziskovanje, ustvarjanje, svetovanje in izobraževanje d.o.o. | Class I | |
| SENSOR | 08437029661035 | BCNINNOVA TECHNOLOGICAL EVOLUTION SL | Class I | |
| Sepsis Prediction Service | 04262435350051 | TCC GmbH | Class IIa | |
| SERENE | 03770035627004 | APX Intégration | Class IIa | |
| SERENE | 03770035627011 | APX Intégration | Class IIa | |
| shizhijue | 06978526990027 | Beijing Visual Perception Intelligence Technology Co., Ltd. | Class I | |
| SilverCloud Platform | 05391543850005 | American Well Corporation Ireland Limited | Class I | |
| Sinapse Diagnostics | 04751051980020 | SIA AKA Sinapse | Class IIa | |
| sinCephalea | 04260583790132 | Perfood GmbH | Class I | |
| Sistema di Telemedicina RemoteCare | 08055162710085 | ALFAHEALTH S.p.A. | Class IIa | |
| SIXSTER | 80543413500058 | PROMEDITAL SRL | Class I | |
| Skinive | 05356660000726 | Skinive LTD. | Class I | |
| SkinScreener API | 09120115610060 | medaia GmbH | Class IIa | |
| SkinScreener API | 09120115610121 | medaia GmbH | Class IIa | |
| SkinScreener v3 | 09120115610077 | medaia GmbH | Class IIa | |
| SkinScreener v3 | 09120115610084 | medaia GmbH | Class IIa | |
| SkinScreener v3 | 09120115610107 | medaia GmbH | Class IIa | |
| SkinScreener v3 | 09120115610114 | medaia GmbH | Class IIa | |
| SkinScreener v3 | 09120115610138 | medaia GmbH | Class IIa | |
| SkinScreener v3 | 09120115610145 | medaia GmbH | Class IIa | |
| Skinuvita Phototherapy Solution | 04262439760078 | Skinuvita GmbH | Class IIa | |
| SkinVision | 08720892314703 | Skin Vision B.V. | Class IIa | |
| Skrift.md | 07090071690005 | Eirskrift AS | Class I | |
| sleep² Intensivprogramm (Android) | 09120138160023 | Nukkuaa GmbH | Class I | |
| sleep² Intensivprogramm (iOS) | 09120138160016 | Nukkuaa GmbH | Class I | |
| SleepFactory MD | 18594238510008 | Klinika TES s.r.o. | Class I | |
| SłuchKids - program mulitmedialny - MED | 05906407027068 | Moje Bambino Sp. z o.o. | Class I | |
| Smart Care Plans | 07350127221011 | Platform24 Healthcare AB | Class IIa | |
| SMARTLINK | 08057509900005 | SOFTWARE TEAM SRL TECNOLOGIE INFORMATICHE AVANZATE | Class IIb | |
| SmartMed Hospital | 08720892053800 | SmartMed B.V. | Class IIa | |
| SmartMed Pharmacy | 08720892053817 | SmartMed Pharmacy B.V. | Class IIa | |
| Smart Symptom Check | 06429830179207 | JST Healthcare Solutions Oy | Class IIa | |
| Smart Symptom Check | 06429830179214 | JST Healthcare Solutions Oy | Class IIa | |
| Smart Symptom Check | 06429830179221 | JST Healthcare Solutions Oy | Class IIa | |
| SmartVisSolution | 04779055540118 | DTS SOLUTIONS | Class I | |
| SmED | 76499988390204 | In4medicine AG | Class I | |
| SMILECLOUD BLUEPRINT | 05940805430006 | SC SMILECLOUD SRL | Class I | |
UDI Compass