| SMILECLOUD BLUEPRINT 1.1 | 05940805430013 | SC SMILECLOUD SRL | Class I | |
| Smoke Free - Rauchen aufhören | 04262480390019 | Smoke Free 23 GmbH | Class I | |
| Soarian Clinicals | 00853023006500 | Cerner Corporation | Class I | |
| Soarian Critical Care | 00853023006517 | Cerner Corporation | Class I | |
| Social Emotional Regulation Assessment (SERA) | 05391551830006 | Education, Psychology and Therapy (EPT) Clinic Ltd. | Class Im | |
| Social Worlds VR | 08720892309303 | CleVR B.V. | Class I | |
| Social Worlds VR | 08720892309310 | CleVR B.V. | Class I | |
| Software di servizi medici digitali | 08050714540035 | DROP S.R.L.S. | Class I | |
| Software di servizi medici digitali | 08058946270003 | SMED S.r.l. | Class I | |
| SOFTWARE DI SERVIZI MEDICI DIGITALI | 08050714540059 | DROP S.R.L.S. | Class I | |
| SOFTWARE PARA SISTEMAS DE INFORMACIÓN Y GESTIÓN DE IMÁGENES RADIOLÓGICAS - HIRUKO | 77094295747988 | IMAGING EXPERTS AND HEALTHCARE SERVICES S.A.S | Class I | |
| Solence SOMP | 03770042585007 | Solence | Class I | |
| Solsius SelfCare Mobile Application | 03760430740033 | Solsius SAS | Class I | |
| Solsius SelfCare Mobile Application | 03760430740040 | Solsius SAS | Class I | |
| somnovia | 04260670637210 | GAIA AG | Class I | |
| SONY | 04548736106291 | Sony Corporation | Class I | |
| Soteria One Point Zero | 04719880330010 | Soteria Biotech Co., Ltd. | Class IIa | |
| Spirare PC | 07090032450013 | Diagnostica AS | Class IIa | |
| Spirare Web | 07090032450020 | Diagnostica AS | Class IIa | |
| Spoedzorg Topicus Triagemodule | 87208921537158 | Topicus.Healthcare B.V. | Class I | |
| Spreekuur.nl | 87208921537080 | Topicus.Healthcare B.V. | Class I | |
| Squeezy Connect App | 50611199600244 | Living With Ltd | Class I | |
| Squeezy For Men App | 50611199600312 | Living With Ltd | Class I | |
| Squeezy For Women App | 50611199600176 | Living With Ltd | Class I | |
| SSY Engine | 07350161881202 | Shortcut Medtech AB | Class I | |
| Standardize | 00860002304533 | Enlitic, Inc. | Class I | |
| STAR RUCKUS | 88009887200013 | eMotiv Co., Ltd. MF | Class I | |
| stayok | 07649989253026 | Health & Medical Service AG | Class I | |
| Steinfrei | 04170000235798 | Kopylov | Class I | |
| StellarQ | 06429830118800 | StellarQ Ltd | Class I | |
| StellarQ MS | 06429830118817 | StellarQ Ltd | Class I | |
| Step Monitoring | 08437024164012 | Naru Intelligence Solutions S.L. | Class I | |
| Step Proactive | 08437024164036 | Naru Intelligence Solutions S.L. | Class IIa | |
| SteriTRAC | 05600610071817 | BIQ Health Solutions, Lda | Class I | |
| StethoMe AI | 05903839024276 | StethoMe Sp. z o.o. | Class IIa | |
| StimAI | 07290020043009 | FertilAI Ltd | Class IIa | |
| STOMA ALERT | 05905794218103 | "PHIN CONSULTING" SPÓŁKA Z OGRANICZONĄ ODPOWIEDZIALNOŚCIĄ | Class I | |
| STOMA ALERT STOMA STICK bez pilota | 05905794218127 | "PHIN CONSULTING" SPÓŁKA Z OGRANICZONĄ ODPOWIEDZIALNOŚCIĄ | Class I | |
| STOMA ALERT STOMA STICK z pilotem | 05905794218110 | "PHIN CONSULTING" SPÓŁKA Z OGRANICZONĄ ODPOWIEDZIALNOŚCIĄ | Class I | |
| Stroke Triage App | 08720892217905 | ORTEC B.V. | Class I | |
| Stroke Triage App | 08720892217929 | ORTEC B.V. | Class I | |
| Sunrise Sleep Disorder Diagnostic Aid | 05430001896015 | Sunrise SA | Class IIa | |
| SurgiMedia - Light Manager | 03770022348530 | ISIS - INTELLIGENT SURGICAL INSTRUMENTS & SYSTEMS | Class I | |
| Suunta Application | 64298830296917 | Atnuus Health Oy | Class I | |
| Symptomtjekker | 05700002267214 | ODA ApS | Class I | |
| Système Lumeen v2 | 03770025309088 | LUMEEN | Class I | |
| Système Lumeen v2 | 03770025309095 | LUMEEN | Class I | |
| Système Lumeen v2 | 03770025309101 | LUMEEN | Class I | |
| Système Lumeen v2 | 03770025309118 | LUMEEN | Class I | |
| Système Lumeen v2 | 03770025309125 | LUMEEN | Class I | |
UDI Compass